The combination masteron side effects ritonavir (600/100 mg 2 times a day) simultaneously with didanosine can be used without dose adjustment.
Didanosine is recommended on an empty stomach, it can take up to 1 hour before or 2 hours after taking a combination ritonavir, which is taken with food.
Interaction between tenofovir findings (tenofovir disoproxil fumarate 300 mg per day) and the combination of darunavir / ritonavir (300 mg / 100 mg twice a day) showed that the plasma concentration of tenofovir increased by 22%. This change is not clinically significant. With simultaneous use of tenofovir and darunavir renal excretion of both drugs did not change. Tenofovir did not have a significant effect on the concentration of darunavir in the plasma. With simultaneous masteron steroids use of a combination ritonavir and tenofovir dose adjustment is required.
Other nucleoside reverse transcriptase inhibitors
Other nucleoside reverse transcriptase inhibitors (zidovudine, zalcitabine, emtricitabine, stavudine, lamivudine, and abacavir) are eliminated primarily by the kidneys, and therefore the likelihood of interaction with the combination of darunavir / ritonavir is negligible.
Non-nucleoside reverse transcriptase inhibitors
The simultaneous use of a combinationritonavir and delavirdine may lead to increased concentrations of darunavir and delavirdine due to inhibition of isoenzyme CYP3A. Appropriate doses of the combinationritonavir and delavirdine has not been established. Not recommended simultaneous application of a combination ritonavir and delavirdine.
In the study of the interaction of a combination ritonavir (600/100 mg 2 times a day), and etravirine was found to decrease the concentration of etravirine by 37% and no significant changes in the concentration of darunavir. Thus, the combination ritonavir can be simultaneously administered with etravirine 200 mg 2 times a day without changing the dose.
Interaction study was conducted between the combination of darunavir / ritonavir (300 mg / 100 mg twice daily) and efavirenz (600 mg once daily). In the presence of efavirenz was observed a decrease in plasma concentration of darunavir by 13%. On the other hand, efavirenz plasma concentration increased by 21% when it is used simultaneously with a combination of darunavir / ritonavir. This interaction is not clinically significant, and therefore the combination ritonavir and efavirenz can be used simultaneously masteron without correction doses of drugs.
The results of studies of the interaction between the combination of darunavir / ritonavir (400 mg / 100 mg twice daily) and nevirapine (200 mg twice daily) showed that darunavir plasma concentrations were independent of the presence of nevirapine. However, while the use of a combination of darunavir / ritonavir plasma concentration of nevirapine increased by 27% (compared to control). This interaction is considered clinically insignificant, and so the combination of darunavir / ritonavir and nevirapine can be used simultaneously without changing their doses.
Results of the study of interaction between the combination masteron side effects ritonavir (800mg / 100mg once daily) with rilpivirine (150 mg once daily) showed no clinically significant effect on the concentration of darunavir. Rilpivirine concentrations increased by 130% while the use of a combination ritonavir. This interaction is considered clinically insignificant, and so the combination ritonavir and rilpivirine can be used simultaneously without changing their doses.
In general, the effect of improving the pharmacokinetics of ritonavir, darunavir manifested that darunavir plasma concentrations increased by approximately 14 times after a single dose of darunavir (600 mg) and 100 mg ritonavir twice per day. Consequently, must be used masteron propionate in combination with a low dose of ritonavir to increase the bioavailability of darunavir.
The combination of lopinavir / ritonavir
Results of the study the interaction between a combination of darunavir / ritonavir (1200 mg / 100 mg twice daily) or 1200 mg of darunavir and ritonavir combination without lopinavir / ritonavir (400 mg / 100 mg twice a day or 533 mg / twice 133.3 mg per day) showed that decreased by 40% in the presence of lopinavir / ritonavir plasma concentration of darunavir. It is not recommended to use a combination of lopinavir / ritonavir at the same time with a combination ritonavir.
Investigation of the interaction of darunavir (400 mg twice a day), saquinavir (1000 mg twice daily) and RTV (100 mg twice daily) showed that darunavir plasma concentration decreased by 26% in the presence of ritonavir and saquinavir; On the other hand, the combination of darunavir / ritonavir does not affect the plasma concentration of saquinavir. Not recommended for use in conjunction masteron side effects with saquinavir masteron side effects regardless of use a small additional dose of ritonavir.
Investigation of the interaction between the combination of darunavir / ritonavir (400 mg / 100 mg twice daily) and atazanavir (300 mg once daily) showed no significant change in their simultaneous use of darunavir and atazanavir concentrations in plasma. Atazanavir can be used simultaneously with the combination of darunavir / ritonavir.