Is well absorbed in the gastrointestinal tract after oral administration and undergoes initial metabolism during the initial passage through the liver.Losartan bioavailability is about 33%. The drug is not cumulated in the body. The half-life of losartan for 2 hours. As losartan and its metabolite associated with a high degree of plasma protein 92-99%. Masteron steroidis excreted in the urine and bile.
Chronic ischemic heart disease accompanied by symptoms of heart failure (in a combination therapy with diuretics and cardiac glycosides).
: Hypersensitivity to the drug;
Children up to age 18;
Patients with dehydration (for example, treated with high doses of diuretics), early treatment Prezartanom symptomatic hypotension may occur. It is necessary to carry out the correction of dehydration Prezartana to the destination or start the treatment with a low dose.
Pharmacological data indicate that losartan concentration in the blood plasma of patients with liver cirrhosis increases significantly, so patients masteron steroid with a history of liver disease should be given low doses.
Some drugs that affect kininangiotenzin system may increase blood urea and creatinine syvorochnogo in patients with impaired renal function.
It is not known whether losartan is excreted in breast milk. In appointing Prezartana during lactation should decide or termination of breastfeeding, or termination of treatment drugs.
Dosing and dosing regimen
When hypertension initial daily dose – 25 mg, the average daily dose is 50 mg, the multiplicity of reception – 1 times / day.
The maximum antihypertensive effect develops within 3-6 weeks after starting the drug. If necessary, the dose may be increased to 100 mg per day. In this case the preparation can receive two times a day.
The initial dose for patients with heart failure is 12.5 mg 1 time / day. Usually, the dose is titrated at weekly intervals (ie 12.5 mg / day, 25 mg / day, 50 mg / day) to an average maintenance dose of 50 mg 1 time / day, depending on the patient’s tolerability of the drug.
In appointing the drug to patients receiving high doses of diuretics, the initial dose should be reduced to 25 mg 1 time / day.
Patients with hepatic impairment should be given lower doses of losartan.
Elderly patients and patients with renal impairment, including patients on hemodialysis, there is no need for correction of the initial dose.
Prezartan can be administered in conjunction with other antihypertensive agents. Losartan can be applied regardless of the meal.
Prezartan generally well tolerated. You may experience diarrhea, indigestion, muscle pain, swelling, dizziness, sleep disturbances, headache, hyperkalemia (potassium in the blood more than 5.5 mEq / L). In rare cases, it may be a cough, respiratory failure, tachycardia, angioedema (including swelling of the face, lips, throat and / or tongue), urticaria, increased activity of “liver” transaminases, bilirubin in the blood.
Interaction with other drugs:
Co-administration with potassium-sparing diuretics, masteron steroid potassium supplements or salt substitutes containing potassium may lead to hyperkalemia.
With simultaneous use of losartan with other antihypertensive agents observed mutual enhancement of the hypotensive action. The simultaneous use of NSAIDs (especially indomethacin) can cause weakening of the hypotensive action of losartan. The combination of losartan with a diuretic can cause a drop in blood pressure.
Overdose Symptoms: hypotension, tachycardia.
Treatment: symptomatic. Hemodialysis is not effective.