Cyclosporin and ketoconazole, slowing metabolism can in some cases increase its toxicity. Concurrent administration of androgen and steroid anabolic drugs withmasteron contributes to the development of peripheral edema and hirsutism, acne. Estrogens and oral estrogensoderzhaschie contraceptives reduce Prednizola clearance, which may be accompanied by increased expression of his actions.
Mitotane and other inhibitors of adrenocortical function may necessitate increasing dose Prednizola. while the use of live virus vaccines, and in comparison with other types of immunization increases the risk of activation of viruses and the development of infections. Antipsychotic drugs (neuroleptics) and azathioprine increases the risk of developing cataracts in the appointment . While the use of antithyroid drugs is reduced, and on the thyroid hormones – increases clearance Prednizola. hypokalemia caused can increase the severity and duration of muscle blockade on the background of muscle relaxants. Immunosuppressive drugs increase the risk of injection and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.. Tricyclic antidepressants can increase the severity of depression caused by the reception (not shown for the therapy of side-effects data).
Special instructions .
During treatment (especially long) must be monitored ophthalmologist, blood pressure control, the state of water and electrolyte balance, as well as patterns of peripheral blood and the blood glucose level.
In order to reduce the side effects can be administered antacids and increase the flow of K + the body (diet, potassium supplements). Food should be rich in proteins, vitamins, with the restriction of fat, carbohydrates and salt.
The drug is enhanced in patients with hypothyroidism and liver cirrhosis. The drug may exacerbate existing emotional instability or psychotic disorders. When referring to the history of psychoses in at high doses prescribed under the strict supervision of a physician.
Caution should be used in acute and subacute myocardial infarction -perhaps spread necrosis, slowing the formation of scar tissue and rupture of the heart muscle.
In stressful situations during maintenance treatment (eg , surgery, trauma, or infectious diseases) should be carried out correction dose due to the increased need for glucocorticosteroids.
with the sudden cancellation, particularly in the case of the prior use of high doses may develop the syndrome of “cancellation” (anorexia, nausea, lethargy, generalized myshechno- skeletal pain, general weakness), as well as exacerbation of the disease, about which he was appointed.
during treatment masteronshould not be vaccinated due to the reduction of its effectiveness (immune response).
by assigning during intercurrent infections, septic conditions, and tuberculosis, it is necessary at the same time to treat antibiotic bactericidal action.
The children during long-term treatment Prednizolom careful observation of the dynamics of growth and development. Children who during the treatment period were in contact with patients with measles or chickenpox, prophylaxis prescribe specific immunoglobulins.
Due to the weak mineralocorticoid effect for replacement therapy in adrenal insufficiency Prednizol used in combination with a mineralocorticoid.
Patients content of blood glucose should be controlled diabetes and, if necessary, to correct therapy.
Showed radiological control of bone and joint system (spine images, brushes).
In patients with latent infectious diseases of kidneys and the urinary tract can cause pyuria, which may be of diagnostic value.
Masteron increases the content of metabolites 11- and 17-oksiketokortikosteroidov.