In HIV-infected patients with severe immune deficiency at the start of combination antiretroviral therapy may cause an inflammatory reaction to asymptomatic or residual opportunistic infections that can lead to severe clinical complications or worsening of symptoms. Typically, such reactions are observed within the first weeks or months of combination antiretroviral therapy. In oral masteron Examples cytomegalovirus retinitis, generalized and / or local mycobacterial infections and pneumonia caused by Pneumocystis jiroveci. It is necessary to determine the severity of any symptoms of inflammation and implement appropriate therapy.
Autoimmune disorders (such as Graves’ disease) have also been reported in the event of reconstitution inflammatory syndrome of the immune system. However, the time to onset of the disease may vary, and such diseases may begin months after initiation of therapy.
Interaction with other drugs
Darunavir and ritonavir are inhibitors of isozymes, as well as inhibitors of P-glycoprotein. The simultaneous use of a combination oral masteronitonavir and other drugs that are metabolized by isoenzymes mainly, and transferred to P-glycoprotein may result in increased concentrations of these drugs in the plasma, so that may increase or lengthen their therapeutic and side effects.
Darunavir is metabolized isoenzyme . Simultaneous administration of drugs inducing activity, darunavir clearance may increase, resulting in decrease in the plasma concentration of darunavir. Simultaneous treatment with darunavir with inhibitors may reduce the clearance of darunavir, resulting in increased plasma concentration of darunavir in.
Effects on ability to drive and use machines
There has been no research on the effect of the combination of oral masteron ritonavir on the ability to drive and use machines. However, you must take into account the fact that in some patients during treatment, including receiving a combination ritonavir, dizziness was observed. When the dizziness should refrain from carrying out these activities.